Pathogenic antibodies to coagulation factors. Part one: Factor VIII and Factor IX

Pathogenic antibodies to coagulation factors. Part one: factor VIII and factor IX.

Pathogenic antibodies targeting coagulation factors usually are clinically significant because they inhibit function. Circulating anticoagulants were recognized as early as 1906 ([1], cited in [2]). They interfere with the coagulation of normal blood as well as that of the patient, which is the basis of the classical mixing study. Circulating anticoagulants inhibiting factor (F)VIII and factor ...

Plasma clearance rates of coagulation factors VIII and IX in factor-deficient individuals.

The plasma clearance rates of factors IX and VIII were determined in patients with hemophilia A and B who had received factor replacement by prolonged, continuous infusion of factor concentrates. The clearance rates were calculated by dividing the factor infusion rates by the steady-state plasma factor activities corrected for base-line factor activities. The mean factor IX clearance rate in ei...

A therapeutic concentrate of coagulation factors II, IX and X from citrated, factor VIII-depleted plasma.

A simple procedure is described for t he large-scale absorption on t o DEAEcelluiose of coagulation factors II , I X and X from citrated, factor VHI-depleted plasma. The coagulation factors are elutcd frontally f rom the exchanger in a high yield and hi a form suitable f o r therapeutic use, without further fractionation. The lyophilised con­ centrate is very stable without the addition of hepa...

Coagulation Therapy in Hemophilia A and its Relation to Factor VIII Inhibitor in Northeast of Iran

Some human inhibitor antibodies interfere with factor VIII binding to factor IX.

Factor VIII (fVIII) functions as a cofactor of factor IXa in the intrinsic pathway of blood coagulation. Its absence or abnormality causes the bleeding disorder hemophilia A. About 23% of hemophiliacs who receive therapeutic fVIII infusions develop antibodies that inhibit its activity. We previously showed by inhibitor neutralization assays that the fVIII A2 and C2 domain polypeptides contain c...